Phosphoinositide-4-Kinase Catalytic Beta Polypeptide

Cancer Terms -> Gene Product -> Protein -> Protein Complex Subunit -> Phosphoinositide-4-Kinase Catalytic Beta Polypeptide

Phosphoinositide-4-Kinase Catalytic Beta Polypeptide Definition

Phosphoinositide-4-Kinase, Catalytic, Beta Polypeptide, encoded by the PIK4CB gene, belongs to the PI3/PI4-kinase family. This protein phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). It may regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Its enzymatic activity is inhibited by wortmannin. This protein is found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum, and recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2) on the Golgi complex. Two named isoforms exist resulting from alternative splicing. (from Swiss-Prot)

Phosphoinositide-4-Kinase Catalytic Beta Polypeptide Synonyms

Phosphoinositide-4-Kinase Catalytic Beta Polypeptide, EC 2.7.1.67, NPIK, PI4K-Beta, PI4K92, PI4KBeta, PIK4CB, Phosphatidylinositol 4-Kinase Beta, Phosphatidylinositol 4-Kinase, Catalytic, Beta, Phosphatidylinositol 4-Kinase, Type III, Beta, Phosphatidylinositol 4-Kinase, Wortmannin-Sensitive, PtdIns 4-Kinase

Phosphoinositide-4-Kinase Catalytic Beta Polypeptide

Phosphoinositide-4-Kinase Catalytic Beta Polypeptide Definition

Phosphoinositide-4-Kinase Catalytic Beta Polypeptide Synonyms

Terms in Phosphoinositide-4-Kinase Catalytic Beta Polypeptide category