Cancer Terms

Phospholipase-A2 Group-IIA

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Esterase -> Phospholipase -> Phospholipase-A2 -> Phospholipase-A2 Group-IIA

Phospholipase-A2 Group-IIA Definition

Expressed in many cells by human PLA2G2A Gene (PLA2 Type II Family), identical membrane-bound and secreted forms of 144-aa 16-kDa (precursor) Phospholipase A2 Group IIA catalyze calcium-dependent hydrolysis of sn-2 fatty acid acyl ester bonds in 3-sn-phosphoglycerides, releasing free fatty acids and lysophospholipids. Thought to regulate biomembrane phospholipid metabolism and eicosanoid biosynthesis, PLA2G2A is likely involved in a variety of cellular processes, including production of precursors for inflammatory reactions. (NCI)

Phospholipase-A2 Group-IIA Synonyms

Phospholipase A2 Group IIA, GIIC sPLA2, Group IIA Phospholipase A2, Membrane Associated Phospholipase A2, NPS-PLA2, Non-Pancreatic Secretory Phospholipase A2, PLA2B, PLA2G2A, PLA2L, PLA2S, PLAS1, Phosphatidylcholine 2-Acylhydrolase

Terms in Phospholipase-A2 Group-IIA category



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