Pim Kinase Inhibitor SGI-1776
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Pim Kinase Inhibitor SGI-1776 Definition
A small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI-1776 binds to and inhibits the activities of Pim-1, -2 and -3, serine-threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.
Pim Kinase Inhibitor SGI-1776 Synonyms
Pim Kinase Inhibitor SGI-1776, SGI-1776
Terms in Pim Kinase Inhibitor SGI-1776 category
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