Platelet Derived Growth Factor Beta Chain
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Platelet-Derived Growth Factor -> Platelet Derived Growth Factor Beta Chain
Platelet Derived Growth Factor Beta Chain Definition
Expressed as 2 alternative isoforms in platelets by human PDGFB Gene (PDGF/VEGF Family), 241-aa 27-kDa (precursor) Platelet-Derived Growth Factor-Beta Chain is a potent mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFB can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Alpha. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. PDGFB mutations are associated with meningioma. Reciprocal t(17;22)(q22;q13) translocations with COL1A1 result in unregulated growth factor expression and are associated with DFSP. (NCI)
Platelet Derived Growth Factor Beta Chain Synonyms
Platelet Derived Growth Factor Beta Chain, Becaplermin, PDGF B-Chain, PDGF, B Chain, PDGF-2, PDGFB, Platelet-Derived Growth Factor Beta, Platelet-Derived Growth Factor Beta Polypeptide, Platelet-Derived Growth Factor, B Chain, Platelet-Derived Growth Factor, Beta Polypeptide, SIS Gene Product
Terms in Platelet Derived Growth Factor Beta Chain category
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