Cancer Terms

Platelet Factor-4

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Cytokine -> Chemokine -> Alpha Chemokine -> Platelet Factor-4

Platelet Factor-4 Definition

Platelet factor-4 is a 70-amino acid CXC chemokine. It is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. (from OMIM)

Platelet Factor-4 Synonyms

Platelet Factor 4, Chemokine (C-X-C motif) Ligand 4, PF4, Small Inducible Cytokine B4, Small Inducible Cytokine Subfamily B, Member 4

Terms in Platelet Factor-4 category



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