Platelet Factor-4
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Cytokine ->
Chemokine ->
Alpha Chemokine -> Platelet Factor-4
Platelet Factor-4 Definition
Platelet factor-4 is a 70-amino acid CXC chemokine. It is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. (from OMIM)
Platelet Factor-4 Synonyms
Platelet Factor 4, Chemokine (C-X-C motif) Ligand 4, PF4, Small Inducible Cytokine B4, Small Inducible Cytokine Subfamily B, Member 4
Terms in Platelet Factor-4 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.