Cancer Terms

Platelet-Derived Endothelial Cell Growth Factor-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Glycosyltransferase -> Platelet-Derived Endothelial Cell Growth Factor-1

Platelet-Derived Endothelial Cell Growth Factor-1 Definition

Endothelial Cell Growth Factor 1 (Platelet-Derived), encoded by the human ECGF1 gene, catalyses the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This protein may have a role in maintaining the integrity of the blood vessels. It promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells. It also limits glial cell proliferation as gliostatin. Defects in ECGF1 are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive human disease associated with multiple deletions of skeletal muscle mitochondrial DNA (MTDNA). (From LocusLink, Swiss-Prot and NCI)

Platelet-Derived Endothelial Cell Growth Factor-1 Synonyms

Platelet-Derived Endothelial Cell Growth Factor 1, EC 2.4.2.4, ECGF1, Endothelial Cell Growth Factor 1 (Platelet-Derived), Gliostatin, PD-ECGF, TP, TdRPase, Thymidine Phosphorylase, Thymidylate Phosphorylase

Terms in Platelet-Derived Endothelial Cell Growth Factor-1 category



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