Platelet-Derived Growth Factor

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Growth Factor -> Platelet-Derived Growth Factor

Platelet-Derived Growth Factor Definition

Expressed in platelets, human Platelet-Derived Growth Factor (PDGF/VEGF Family) is a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released upon wounding to stimulate adjacent cell growth. PDGF can exist as antiparallel disulfide-linked homodimers (PDGFA, PDGFB) or heterodimers (PDGFA/PDGFB) that bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. (NCI)

Platelet-Derived Growth Factor Synonyms

Platelet-Derived Growth Factor, PDGF

Terms in Platelet-Derived Growth Factor category

Platelet-Derived Growth Factor Alpha
Platelet Derived Growth Factor Beta Chain