Platelet-Derived Growth Factor Alpha
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Gene Product ->
Protein ->
Protein Organized by Function ->
Growth Factor ->
Platelet-Derived Growth Factor -> Platelet-Derived Growth Factor Alpha
Platelet-Derived Growth Factor Alpha Definition
Expressed in platelets as 2 alternative isoforms by human PDGFA Gene (PDGF/VEGF Family), Platelet-Derived Growth Factor Alpha is a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFA can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Beta. A long PDGFA isoform contains a basic insert that acts as a cell retention signal. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. (NCI)
Platelet-Derived Growth Factor Alpha Synonyms
Platelet-Derived Growth Factor Alpha, PDGF A-Chain, PDGF-1, PDGFA, Platelet-Derived Growth Factor A Chain, Platelet-Derived Growth Factor Alpha Polypeptide
Terms in Platelet-Derived Growth Factor Alpha category
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