Platelet-Derived Growth Factor Receptor Alpha Polypeptide

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Receptor Tyrosine Kinase -> Platelet-Derived Growth Factor Receptor Alpha Polypeptide

Platelet-Derived Growth Factor Receptor Alpha Polypeptide Definition

Platelet-Derived Growth Factor Receptor, Alpha Polypeptide, encoded by the PDGFRA gene, is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. (from LocusLink)

Platelet-Derived Growth Factor Receptor Alpha Polypeptide Synonyms

Platelet-Derived Growth Factor Receptor Alpha Polypeptide, Alpha Platelet-Derived Growth Factor Receptor, CD140a Antigen, EC 2.7.1.112, PDGF-R-Alpha, PDGFRA

Terms in Platelet-Derived Growth Factor Receptor Alpha Polypeptide category

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