Platelet-Derived Growth Factor Receptor Beta Polypeptide

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Receptor Tyrosine Kinase -> Platelet-Derived Growth Factor Receptor Beta Polypeptide

Platelet-Derived Growth Factor Receptor Beta Polypeptide Definition

Platelet-Derived Growth Factor Receptor, Beta Polypeptide, encoded by the PDGFRB gene, is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETS, leukemia gene, results in chronic myelomonocytic leukemia. (from LocusLink)

Platelet-Derived Growth Factor Receptor Beta Polypeptide Synonyms

Platelet-Derived Growth Factor Receptor Beta Polypeptide, Beta Platelet-Derived Growth Factor Receptor, CD140b Antigen, EC 2.7.1.112, PDGF-R-Beta, PDGFRB

Terms in Platelet-Derived Growth Factor Receptor Beta Polypeptide category

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