Pleiomorphic Adenoma-Like Protein-1
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Pleiomorphic Adenoma-Like Protein-1 Definition
Widely expressed by human PLAGL1 Gene (Krueppel Family), 411-aa 45-kDa DNA-binding transcriptional activator Pleomorphic Adenoma-Like Protein 1 contains 7 C2H2-type zinc fingers and inhibits cell proliferation through induction of the p53 apoptosis and cell cycle arrest pathways. PLAGL1 also regulates pituitary adenylate cyclase-activating polypeptide type 1 receptor, a potent insulin secretagogue and mediator of autocrine control of insulin secretion in the pancreatic islets. (NCI)
Pleiomorphic Adenoma-Like Protein-1 Synonyms
Pleiomorphic Adenoma-Like Protein 1, PLAG-Like 1, PLAGL1, Pleomorphic Adenoma Gene-Like 1 Protein, ZAC Tumor Supressor, Zinc Finger Protein PLAGL1
Terms in Pleiomorphic Adenoma-Like Protein-1 category
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