Cancer Terms

Polo-like Kinase 1 Inhibitor GSK461364

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Protein Kinase Inhibitor -> Serine Threonine Kinase Inhibitor -> Polo-like Kinase 1 Inhibitor GSK461364

Polo-like Kinase 1 Inhibitor GSK461364 Definition

A small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.

Polo-like Kinase 1 Inhibitor GSK461364 Synonyms

Polo-like Kinase 1 Inhibitor GSK461364, GSK461364

Terms in Polo-like Kinase 1 Inhibitor GSK461364 category



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