Polo-like Kinase 1 Inhibitor GSK461364
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Enzyme Inhibitor ->
Protein Kinase Inhibitor ->
Serine Threonine Kinase Inhibitor -> Polo-like Kinase 1 Inhibitor GSK461364
Polo-like Kinase 1 Inhibitor GSK461364 Definition
A small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.
Polo-like Kinase 1 Inhibitor GSK461364 Synonyms
Polo-like Kinase 1 Inhibitor GSK461364, GSK461364
Terms in Polo-like Kinase 1 Inhibitor GSK461364 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.