Polo-like Kinase 1 Inhibitor MK1496
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Polo-like Kinase 1 Inhibitor MK1496 Definition
An orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.
Polo-like Kinase 1 Inhibitor MK1496 Synonyms
Polo-like Kinase 1 Inhibitor MK1496, MK1496, PLK1 Inhibitor MK1496
Terms in Polo-like Kinase 1 Inhibitor MK1496 category
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