Polynucleotide Adenylyltransferase Alpha
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Riboadenylate Transferase -> Polynucleotide Adenylyltransferase Alpha
Polynucleotide Adenylyltransferase Alpha Definition
Encoded by human PAPOLA Gene (Poly A Polymerase Family), phosphorylated nuclear and cytoplasmic Polynucleotide Adenylyltransferase Alpha is a possible monomeric polymerase that creates the 3 prime poly(A) tail during eukaryotic mRNA maturation. The N-terminal region is required for nonspecific polymerase activity, while the N- and C-termini are required for specific polymerase activity. Specificity may occur through C-terminus interaction with CPSF, regulated by phosphorylation/dephosphorylation. The poly(A) reaction involves endoribonucleolytic pre-RNA cleavage at the poly(A) site and synthesis of the poly(A) tail. PAPOLA is required for endoribonucleolytic cleavage at some polyadenylylation sites. (NCI)
Polynucleotide Adenylyltransferase Alpha Synonyms
Polynucleotide Adenylyltransferase Alpha, PAPOLA, Poly(A) Polymerase Alpha
Terms in Polynucleotide Adenylyltransferase Alpha category
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