Procarbazine

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Alkylating Agent -> Antineoplastic Alkylating Agent -> Triazene Compound -> Procarbazine

Procarbazine Definition

The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.

Procarbazine Synonyms

Procarbazine Hydrochloride, Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI), Ibenzmethyzine hydrochloride, MIH hydrochloride, Matulane, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride, N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine Hydrochloride, N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide Hydrochloride, NCI-C01810, Natulan, Natulanar, Natunalar, PCB, PCB Hydrochloride, PCB hydrochloride, PCZ, PROCARBAZINE HYDROCHLORIDE, Ro 4 6467/1, Ro 4-6467/1, benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI), p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride, p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI), p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)

Procarbazine

Procarbazine Definition

Procarbazine Synonyms

Terms in Procarbazine category