Procarbazine Base
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Procarbazine Base Definition
A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
Procarbazine Base Synonyms
Procarbazine, Benzethyzin, Ibenzmethyzin, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide, N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine, N-Methylhydrazine, N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide, PROCARBAZINE, Procarbazin, p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide, procarbazine
Terms in Procarbazine Base category
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