Cancer Terms

Prochlorperazine Maleate

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Agent Affecting Nervous System -> Antiemetic Agent -> Prochlorperazine Maleate

Prochlorperazine Maleate Definition

The maleate salt form of prochlorperazine, a synthetic, piperazine phenothiazine derivative with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine binds to and blocks the postsynaptic dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Prochlorperazine maleate also blocks anticholinergic and alpha-adrenergic receptors. Its antagonistic actions on the alpha-1 adrenergic receptors results in sedation, muscle relaxation, and hypotension.

Prochlorperazine Maleate Synonyms

Prochlorperazine Maleate, Compazine, PROCHLORPERAZINE MALEATE, Prochlorperazine Dimaleate

Terms in Prochlorperazine Maleate category



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