Cancer Terms

Proliferating Cell Nuclear Antigen

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Proliferating Cell Nuclear Antigen Definition

This protein is found in the nucleus and is a cofactor of DNA polymerase delta. It acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. (from LocusLink)

Proliferating Cell Nuclear Antigen Synonyms

Proliferating Cell Nuclear Antigen, Cyclin, DNA Polymerase Delta Auxiliary Protein, PCNA

Terms in Proliferating Cell Nuclear Antigen category



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