Cancer Terms

Propantheline Bromide

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Agent Affecting Nervous System -> Anticholinergic Agent -> Antimuscarinic Agent -> Propantheline Bromide

Propantheline Bromide Definition

The bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. Propantheline bromide competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. An aspartic acid residue present in the N-terminal portion of the third trans-membrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax bronchial muscle and reduce tone and motility of intestinal smooth muscle.

Propantheline Bromide Synonyms

Propantheline Bromide, PROPANTHELINE BROMIDE

Terms in Propantheline Bromide category



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