Propylthiouracil
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Propylthiouracil Definition
A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.
Propylthiouracil Synonyms
Propylthiouracil, 6-Propyl-2-Thiouracil, 6-Propyl-2-thiouracil, PROPYLTHIOURACIL
Terms in Propylthiouracil category
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