Cancer Terms

Prostaglandin-Endoperoxide Synthase-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Oxidoreductase -> Oxygenase -> Cyclooxygenase -> Prostaglandin-Endoperoxide Synthase-1

Prostaglandin-Endoperoxide Synthase-1 Definition

COX-1 is known to be present in most tissues as the housekeeper enzyme, maintains normal gastric mucosa and influences kidney function, while COX-2 is inducible by inflammation. They share 60% homology. The expression of Cox-1 is induced by cytokines and mitogens, hence it is likely to play a role in inflammatory diseases such as rheumatoid arthritis. It contains one EGF-like domain. Both isoforms have the same affinity to convert arachidonic acid to prostaglandin. COX-1. Both forms of COX proteins are membrane associated heme proteins containing cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Non steroidal anti-inflammatory drugs) such as aspirin.

Prostaglandin-Endoperoxide Synthase-1 Synonyms

Prostaglandin-Endoperoxide Synthase 1, COX, COX-1, COX1, COX3, Cyclo-Oxygenase-1, Cyclooxygenase, Cyclooxygenase 3, Cyclooxygenase-1, Fatty Acid Cyclooxygenase, PGH Synthase, PGH Synthase 1, PGHS-1, PHS1, PTGS, PTGS1, Prostaglandin G/H Synthase 1, Prostaglandin G/H Synthase and Cyclooxygenase, Prostaglandin H2 Synthase, Prostaglandin H2 Synthase 1, Prostaglandin-Endoperoxide Synthase

Terms in Prostaglandin-Endoperoxide Synthase-1 category



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