Prostate-Specific Antigen
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Kallikrein -> Prostate-Specific Antigen
Prostate-Specific Antigen Definition
Alternate isoforms of the single-chain 261-aa 30-kD Kallikrein 3 (Prostate Specific Antigen) glycoprotein precursor are encoded by human KLK3 Gene (Kallikrein Family). Frameshifted isoform 2 has a shorter distinct C-terminus. A Kallikrein-like serine protease in seminal plasma, PSA may function in liquefaction of seminal coagulum by (preferential Tyr-X) cleavage of seminal vesicle protein. Kallikrein proteases have diverse functions. Mounting evidence implicates kallikreins in carcinogenesis; some have potential as cancer biomarkers. The serum level of PSA is useful in diagnosis and monitoring of prostatic carcinoma, benign prostate hyperplasia, or infection or inflammation of the prostate. (NCI)
Prostate-Specific Antigen Synonyms
Prostate-Specific Antigen, Antigen, Prostate-Specific, EC 3.4.21.34, Fletcher Factor, Gamma-Seminoprotein, KLK3, Kallikrein 3, Kininogenin, P-30 Antigen, PSA, Plasma Kallikrein Precursor, Plasma Prekallikrein, Prostate Specific Antigen, Prostate Specific Antigen Preproprotein, Semenogelase, Seminin, prostate-specific antigen
Terms in Prostate-Specific Antigen category
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