Cancer Terms

Protein Kinase C Beta 1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Serine-Threonine Protein Kinase -> Protein Kinase-C -> Protein Kinase C Beta 1

Protein Kinase C Beta 1 Definition

Protein Kinase C-beta is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B cells after BCR cross-linking (By similarity). Phosphorylation on Thr-500 of isoform beta-I, within the activation loop, renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol.

Protein Kinase C Beta 1 Synonyms

Protein Kinase C-Beta 1, PKCB, PRKCB1, Protein Kinase C Beta,polypeptide 1

Terms in Protein Kinase C Beta 1 category



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