Cancer Terms

Protein Kinase-B Gamma

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Protein Kinase-B Gamma Definition

Highly expressed in brain, lung, kidney and fetal heart, liver, brain by human AKT3 Gene (AKT/RAC Family) as alternative isoforms 1 (479-aa, 55.8-kD) and 2 (465-aa; shorter C-terminus), cytoplasmic Protein Kinase B Gamma contains a PH domain that binds PI(3)K alpha and promotes plasma membrane translocation after cell stimulation. Fully active when phosphorylated on threonine and serine residues, AKT3 phosphorylates several proteins to regulate cell signaling responses to insulin, PDGF, and IGF1 involved in cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake. (NCI)

Protein Kinase-B Gamma Synonyms

Protein Kinase B Gamma, AKT3, V-Akt Murine Thymoma Viral Oncogene Homolog 3

Terms in Protein Kinase-B Gamma category



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