Protein Phosphatase Regulatory Protein

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Protein Phosphatase Regulatory Protein Definition

Protein Phosphatase Regulatory Proteins are constant regulatory/scaffolding subunits of PP2 that coordinate assembly of the phosphatase catalytic subunit and various regulatory subunits or cell signaling molecules. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)

Protein Phosphatase Regulatory Protein Synonyms

Terms in Protein Phosphatase Regulatory Protein category

Protein Phosphatase-2A-48kDa Regulatory Subunit
Protein Phosphatase-2A Regulatory Subunit-PR53
Protein Phosphatase-2 Regulatory Subunit-A Beta
Protein Phosphatase-2 Regulatory Subunit-B Alpha
Protein Phosphatase-2 Regulatory Subunit-B Beta
Protein Phosphatase-2 Regulatory Subunit-B Delta
Protein Phosphatase-2 Regulatory Subunit-B Epsilon
Protein Phosphatase-2 Regulatory Subunit-B Gamma