Protein Phosphatase-2 Catalytic Subunit Alpha

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Phosphatase -> Phosphoprotein Phosphatase -> Protein Serine-Threonine Phosphatase -> Protein Phosphatase-2 Catalytic Subunit Alpha

Protein Phosphatase-2 Catalytic Subunit Alpha Definition

Encoded by human PPP2CA Gene (PP1 Family), 309-aa 36-kDa cytoplasmic Protein Phosphatase 2 Catalytic Subunit Alpha forms alpha complexes with a structural PR65/A subunit and beta complexes with an alpha4 protein; association with a regulatory subunit that controls substrate selectivity and activity forms as a specific trimeric holoenzyme. PPP2CA is regulated by inactivating threonine or tyrosine phosphorylation, carboxy methylation, ceramide, and protein inhibitors. Carboxyl methylation may play a role in holoenzyme assembly; it varies during the cell cycle. PP2A can dephosphorylate p53, and modulate phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP2 kinase activity. Core PP2A enzyme consists of the catalytic subunit and a common 65-kDa regulatory subunit; additional regulatory subunits or signaling molecules further modify function. (NCI)

Protein Phosphatase-2 Catalytic Subunit Alpha Synonyms

Protein Phosphatase 2 Catalytic Subunit Alpha, PP2A-Alpha, PP2CA, PPP2CA, RP-C, Replication Protein C, Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha

Protein Phosphatase-2 Catalytic Subunit Alpha

Protein Phosphatase-2 Catalytic Subunit Alpha Definition

Protein Phosphatase-2 Catalytic Subunit Alpha Synonyms

Terms in Protein Phosphatase-2 Catalytic Subunit Alpha category