Cancer Terms

Protein Phosphatase-2A Regulatory Subunit-PR53

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Protein Phosphatase Regulatory Protein -> Protein Phosphatase-2A Regulatory Subunit-PR53

Protein Phosphatase-2A Regulatory Subunit-PR53 Definition

Widely expressed (as alpha, beta, delta, and epsilon isoforms) by human PPP2R4 Gene, Protein Phosphatase 2A Regulatory Subunit PR53 is a specific and reversible phosphotyrosyl phosphatase activator of heterodimeric PP2A core enzyme in the presence of ATP and Mg(+2). Implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)

Protein Phosphatase-2A Regulatory Subunit-PR53 Synonyms

Protein Phosphatase 2A Regulatory Subunit PR53, PP2A, PP2A Subunit B Prime, PPP2R4, PR53, PTPA, Phosphotyrosyl Phosphatase Activator, Protein Phosphatase 2A Regulatory Subunit B Prime

Terms in Protein Phosphatase-2A Regulatory Subunit-PR53 category



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