Protein Phosphatase-2A-48kDa Regulatory Subunit

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Protein Phosphatase Regulatory Protein -> Protein Phosphatase-2A-48kDa Regulatory Subunit

Protein Phosphatase-2A-48kDa Regulatory Subunit Definition

Encoded by human PR48 Gene (PP2A Regulatory Subunit B Family), 414-aa nuclear Protein Phosphatase 2A 48kDa Regulatory Subunit is a B regulatory subunit of PP2A. PR48 specifically interacts with the N-terminal region of and dephosphorylates CDC6, modulating initiation of DNA replication and cell cycle control. A major heterotrimeric Ser/Thr phosphatase implicated in negative control of many cellular processes including cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A that may differ in substrate specificity, subcellular location, or tissue specific expression. (NCI)

Protein Phosphatase-2A-48kDa Regulatory Subunit Synonyms

Protein Phosphatase-2A-48kDa Regulatory Subunit, B Double Prime, NY-REN-8, NY-REN-8 Antigen, PP2A B Double Prime Subunit PR48, PP2A Subunit B PR48 Isoform, PR48, Serine/Threonine Protein Phosphatase 2A 48kDa Regulatory Subunit, Serine/Threonine Protein Phosphatase 2A 48kDa Regulatory Subunit B

Terms in Protein Phosphatase-2A-48kDa Regulatory Subunit category

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