Cancer Terms

Protein Receptor Tyrosine Kinase-TIE1

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Protein Receptor Tyrosine Kinase-TIE1 Definition

Specifically expressed in developing endothelial cells by human TIE Gene (TIE Tyr Kinase Family), 1138-aa 125-kDa (precursor) type I transmembrane Protein Receptor Tyrosine Kinase TIE 1 contains 2 Ig-like C2-type domains, 3 fibronectin type III domains, and 3 EGF-like domains. TIE1 receptor may be involved in multiple protein-protein interactions, possibly including endothelial cell adhesion, blood clotting, and inflammation. TIE1 receptor is important in angiogenesis, particularly endothelial vascular formation. Combinatorial ANG-1 and TIE1 orphan receptor function is critical for right-side venous system development. (NCI)

Protein Receptor Tyrosine Kinase-TIE1 Synonyms

Protein Receptor Tyrosine Kinase TIE 1, JTK14, TIE1, Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains, Tyrosine-Protein Kinase Receptor TIE1

Terms in Protein Receptor Tyrosine Kinase-TIE1 category



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