Cancer Terms

Protein Truncation

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Protein Truncation Definition

Protein truncation can occur as a result of those mutations that lead to the termination of mRNA translation, including (1) Nonsense mutation where single nucleotide substitution produces a stop codon (TGA, TAA or TAG) and mRNA translation stops at the point of mutation; (2) Frameshift mutation where one or more nucleotides are either inserted or deleted. If the number of bases is not divisible by 3, a change in the reading frame alters the remainder of the translation of the mRNA, and frequently a stop codon is introduced prematurely; (3) Splice site mutation where one or more nucleotides are inserted or deleted, leading to the presence of a stop codon at a splice site.

Protein Truncation Synonyms

Protein Truncation

Terms in Protein Truncation category



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