Cancer Terms

Proteinase-3

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Serine Protease -> Proteinase-3

Proteinase-3 Definition

Encoded by human PRTN3 Gene (Peptidase S1 Family), 256-aa 29-kD Proteinase 3 precursor is coordinately expressed with and packed in neutrophilic azurophil granules with ELA2 and AZU during myeloid development. An antibiotic neutral serine protease, PRTN3 appears to degrade elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV by preferential cleavage at Ala-X and Val-X bonds. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Proteinase-3 Synonyms

Proteinase 3, ACPA, AGP7, Azurophil Granule Protein 7, C-ANCA, C-ANCA Antigen, Leukocyte Proteinase 3, MBT, Myeloblastin, NP-4, Neutrophil Proteinase 4, Neutrophil Serine Proteinase, PR-3, PR3, PRTN3, Serine Proteinase, Neutrophil, Wegener Autoantigen, Wegener Granulomatosis Autoantigen, p29

Terms in Proteinase-3 category



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