Pyrimethamine-Sulfadoxine
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Anti-Infective Agent ->
Antiparasitic Agent ->
Antiprotozoal Agent ->
Antimalarial Agent -> Pyrimethamine-Sulfadoxine
Pyrimethamine-Sulfadoxine Definition
A combination product containing pyrimethamine and sulfadoxine. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. Sulfadoxine competitively antagonizes paraaminobenzoic acid (PABA), resulting in disruption of folic acid synthesis and ultimately DNA synthesis. Sulfadoxine acts synergistically with pyrimethamine. (NCI04)
Pyrimethamine-Sulfadoxine Synonyms
Pyrimethamine-Sulfadoxine, Fansidar, Pyrimethamine Sulfadoxine
Terms in Pyrimethamine-Sulfadoxine category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.