Quinidine Gluconate
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Anti-Infective Agent ->
Antiparasitic Agent ->
Antiprotozoal Agent ->
Antimalarial Agent -> Quinidine Gluconate
Quinidine Gluconate Definition
The gluconate salt form of quinidine, an alkaloid with antimalarial and antiarrhythmic (Class la) properties. Quinidine gluconate exerts its anti-malarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the hemepolymer (hemozoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite. Quinidine gluconate exerts its antiarrhythmic effects by depressing the flow of sodium ions into cells during phase 0 of the cardiac action potential, thereby slowing the impulse conduction through the atrioventricular (AV) node, reducing the maximal rate of phase 0 depolarization and prolonging the refractory period. Quinidine gluconate also reduces the slope of phase 4 depolarization in Purkinje-fibres resulting in slowed conduction and reduced automaticity in the heart.
Quinidine Gluconate Synonyms
Quinidine Gluconate, 9S-6'-Methoxy-cinchonan-9-ol, Mono-D-gluconate(salt), Duraquin, QUINIDINE GLUCONATE, Quinaglute
Terms in Quinidine Gluconate category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.