Cancer Terms

Quinidine Sulfate

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Anti-Infective Agent -> Antiparasitic Agent -> Antiprotozoal Agent -> Antimalarial Agent -> Quinidine Sulfate

Quinidine Sulfate Definition

The sulfate salt form of quinidine, an alkaloid with antimalarial and antiarrhythmic (Class la) properties. Quinidine sulfate exerts its anti-malarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the hemepolymer (hemozoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite. Quinidine sulfate exerts its antiarrhythmic effects by depressing the flow of sodium ions into cells during phase 0 of the cardiac action potential, thereby slowing the impulse conduction through the atrioventricular (AV) node, reducing the rate of phase 0 depolarization and prolonging the refractory period. Quinidine sulfate also reduces the slope of phase 4 depolarization in Purkinje-fibres resulting in slowed conduction and reduced automaticity in the heart.

Quinidine Sulfate Synonyms

Quinidine Sulfate, (9S)-6'-Methoxycinchonan-9-ol Sulfate (2:1) (salt), QUINIDINE SULFATE, Quinidex

Terms in Quinidine Sulfate category



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