Cancer Terms

Quinine

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Anti-Infective Agent -> Antiparasitic Agent -> Antiprotozoal Agent -> Antimalarial Agent -> Quinine

Quinine Definition

A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

Quinine Synonyms

Quinine, (-)-Quinine, QUIN, QUININE

Terms in Quinine category



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