Cancer Terms

Quinine Sulfate

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Quinine Sulfate Definition

The sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

Quinine Sulfate Synonyms

Quinine Sulfate, QUININE SULFATE

Terms in Quinine Sulfate category



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