Cancer Terms

RAC-Alpha Serine-Threonine Kinase

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Serine-Threonine Protein Kinase -> Protein Kinase B -> RAC-Alpha Serine-Threonine Kinase

RAC-Alpha Serine-Threonine Kinase Definition

RAC-Alpha Serine/Threonine Kinase (AKT1) encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. The activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. AKT1 also promotes cell survival and regulates nitric oxide from endothelium, target of the PDGF-activated phosphatidylinositol 3-kinase. (From LocusLink and NCI)

RAC-Alpha Serine-Threonine Kinase Synonyms

RAC-Alpha Serine/Threonine Kinase, AKT1, C-AKT, PKB, PKB Protein, PRKBA, Protein Kinase B Alpha, RAC, RAC-Alpha Protein Kinase, RAC-PK-Alpha

Terms in RAC-Alpha Serine-Threonine Kinase category



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