RAR and RXR Degradation Pathway
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RAR and RXR Degradation Pathway Definition
Once retinoids are bound by the RAR/RXR heterodimer they became transcriptional activated. As a consequence they are degraded by the proteasome. Phosphorylation in the activation domain one (AF1) and presence of the activation domain 2 (AF2) trigger the ubiquitination of the receptors. Moreover, heterodimerization of RAR and RXR accelerate degradation of the receptors. (BioCarta)
RAR and RXR Degradation Pathway Synonyms
RAR and RXR Degradation Pathway, Degradation of the RAR and RXR by the proteasome
Terms in RAR and RXR Degradation Pathway category
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