RET Oncoprotein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Receptor Tyrosine Kinase -> RET Protein -> RET Oncoprotein

RET Oncoprotein Definition

Human RET Oncoprotein is a product of mutated variants (Oncogene RET) of RET Gene, which encodes Tyrosine-Protein Kinase Receptor RET, a type I membrane protein receptor for Glial Cell Line-Derived with an extracellular cadherin-like domain and important in neural crest development. Some oncogenic RET point mutations cause constitutive kinase activation. PTC1 oncogene involves fusion of RET kinase to the H4 dimerization leucine zipper. In PTC6, RET is fused to the N-terminal part of Transcriptional Intermediary Factor-1-Alpha. In PTC7, RET is fused to a C-terminal part of TIF1-Gamma. Oncogenic RET mutations are associated with Hirschsprung's disease, Multiple Endocrine Neoplasia, pheochromocytoma, hyperparathyroidism and medullary thyroid cancer. RET Oncoprotein disrupts normal cell function.

RET Oncoprotein Synonyms

RET Oncoprotein

RET Oncoprotein

RET Oncoprotein Definition

RET Oncoprotein Synonyms

Terms in RET Oncoprotein category