RET Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Receptor Tyrosine Kinase -> RET Protein

RET Protein Definition

Encoded by human RET Gene, Tyrosine-Protein Kinase Receptor RET is a type I membrane protein receptor for Glial Cell Line-Derived Neurotrophic Factor with an extracellular cadherin-like domain and important in neural crest development. Activation of the RET kinase results in autophosphorylation of tyrosine residues critical for signaling. RET mutations are associated with Hirschsprung's disease and Multiple Endocrine Neoplasia, pheochromocytoma, hyperparathyroidism and medullary thyroid cancer.

RET Protein Synonyms

Tyrosine-Protein Kinase Receptor RET, Cadherin Family Memebr 12, Glial Cell Line Derived Neurotrophic Factor Receptor Component, Hydroxyaryl-Protein Kinase, RET, RET Gene Product, RET Protein

Terms in RET Protein category

RET Oncoprotein