RING Box Protein-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> RING Box Protein-1

RING Box Protein-1 Definition

Widely expressed by human RBX1 Gene (RING-Box Family), conserved cytoplasmic and nuclear 108-aa 12.3-kDa RING Box Protein 1, containing a RING-type zinc finger, mediates protein turnover of cell cycle, signal transduction, and transcription proteins by ubiquitination and proteasomal degradation. A component of various SCF, SCF-like, and CBC multisubunit E3 ubiquitin ligase complexes, RBX1 may recruit E2 enzymes to the complex through its RING-type zinc finger and heterodimerizes with cullins in the third step of ubiquitin conjugation reactions to catalyze ubiquitin polymerization. RBX1 promotes neddylation of CUL1 and probably CUL2. It also probably interacts with CDC34 and may stimulate CDC34 autoubiquitination. (NCI)

RING Box Protein-1 Synonyms

RING Box Protein 1, RBX1, RING Finger Protein, RING Finger Protein 75, ROC1, Regulator of Cullins 1, ZYP Protein

RING Box Protein-1

RING Box Protein-1 Definition

RING Box Protein-1 Synonyms

Terms in RING Box Protein-1 category