RNA Recognition Motif

Cancer Terms -> Anatomic Structure System or Substance -> Microanatomy -> Macromolecular Structure -> Protein Structure -> Protein Domain -> Ligand Binding Domain -> RNA Recognition Motif

RNA Recognition Motif Definition

RNA Binding Domains, such as the RRM, RGG box, and KH domain, mediate the interaction of RNAs with RNA-binding proteins. RRMs of about 90 amino acids consist of a four-stranded beta sheet adjacent to two alpha helixes. Within RRMs, conserved RNP-1 and RNP-2 motifs on the central beta sheets lie side by side; their side chains contact RNA. Found in hnRNP proteins, the RGG box is an RNA-binding motif containing five Arg-Gly-Gly repeats with intervening aromatic residues. The KH domain is found in several RNA-binding proteins in multiple repeats interspersed with RGG boxes. (NCI)

RNA Recognition Motif Synonyms

RNA Recognition Motif, Putative RNA-Binding Region, RBD, RNA Binding Domain, RNP Domain, RNP Motif, RNP-1 Signature, RRM

Terms in RNA Recognition Motif category

Double-Stranded RNA Binding Domain
KH Domain