Receptor Tyrosine Kinase Down Regulation

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Receptor Tyrosine Kinase Down Regulation Definition

Due to internalization of ligand-receptor complexes, increased receptor turnover, or decreased receptor expression following exposure to a ligand or agent, Receptor Tyrosine Kinase Down Regulation involves a decrease in the number of ligand-specific cell membrane proteins that bind to, and mediate, the effects of a regulatory molecule and that have intrinsic cytoplasmic protein-tyrosine kinase activity integral to, and critical for, receptor function; the ligand-induced phosphorylation event alters the function of protein substrates involved in signal transduction pathways.