Receptor Tyrosine Kinase-MERTK
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Receptor Tyrosine Kinase-MERTK Definition
Expressed in monocytes, bone marrow, and tissues of epithelial and reproductive origin by human MERTK Gene (AXL/UFO Family), 999-aa 110-kDa (precursor) Receptor Tyrosine Kinase MERTK contains 2 extracellular N-terminal Ig-like C2-type domains and 2 membrane proximal fibronectin type III domains, a putative transmembrane segment, a tyrosine kinase KWIAIES domain, several N-glycosylation sites, and tyrosine phosphorylation sites. Not expressed in normal B- and T-lymphocytes, MERTK is expressed in numerous neoplastic B-and T-cell lines. MERTK defects cause retinitis pigmentosa. (NCI)
Receptor Tyrosine Kinase-MERTK Synonyms
Receptor Tyrosine Kinase MerTK, EC 2.7.1.112, MERTK, c-mer Proto-oncogene Tyrosine Kinase
Terms in Receptor Tyrosine Kinase-MERTK category
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