Receptor-Interacting Serine-Threonine Protein Kinase-2

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Receptor-Interacting Serine-Threonine Protein Kinase-2

Receptor-Interacting Serine-Threonine Protein Kinase-2 Definition

Expressed in heart, brain, placenta, lung, peripheral leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node by RIPK2 Gene (Ser/Thr Kinase Family), autophosphorylated. 540-aa 61-kDa cytoplasmic Receptor-Interacting Serine/Threonine Kinase 2, containing 1 CARD domain, activates NF-Kappa B and potentiates apoptosis by activating pro-caspase-1 and pro-caspase-8. RIPK2 binds to BIRC3/c-IAP1, BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5, and TRAF6 and binds to CFLAR/CLARP and CASP1 via their CARD domains. RIPK2 may be a component of the TNFRSF1A and TNRFSF5/CD40 receptor complexes. (NCI)

Receptor-Interacting Serine-Threonine Protein Kinase-2 Synonyms

Receptor-Interacting Serine/Threonine Protein Kinase 2, CARD-Containing IL-1 Beta Ice-Kinase, CARD-Containing Interleukin-1 Beta Converting Enzyme Associated Kinase, RIP-Like Interacting CLARP Kinase, RIP2, RIPK2, Receptor Interacting Protein 2, Receptor-Interacting Protein 2

Terms in Receptor-Interacting Serine-Threonine Protein Kinase-2 category

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