Recombinant Nematode Anticoagulant Protein c2
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Recombinant Nematode Anticoagulant Protein c2 Definition
An 85-amino acid recombinant peptide derived from protein c2 of the hemophagocytic hookworm Ancylostoma caninum (a common canine parasite) with anticoagulant activity. Recombinant nematode anticoagulant protein c2 (rNAPc2) binds to circulating activated factor X (FXa) or zymogen factor X (FX) to form a binary complex which subsequently binds to and inhibits membrane-bound activated factor VII/tissue factor complex (FVIIa/TF). When administered prophylactically, this agent may reduce the incidence of deep venous thrombosis without hemostatic compromise. Because rNAPc2 inhibits the formation of the FVIIa/TF protease complex, which may play a role in the cellular signaling of both metastatic and angiogenic processes, it may impede tumor progression.
Recombinant Nematode Anticoagulant Protein c2 Synonyms
Recombinant Nematode Anticoagulant Protein c2, rNAPc2
Terms in Recombinant Nematode Anticoagulant Protein c2 category
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