Rectal Route of Drug Administration
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Rectal Route of Drug Administration Definition
The introduction of a substance into the gastrointestinal tract by the way of the rectum, usually for systemic action. Depending on the molecular structure, drugs cross the rectal wall via either intercellular or tight junctions interconnecting the mucosal cells. Drug absorption is usually around 50% of normal oral dose. Due to the drainage pattern of the rectal veins, the hepatic first-pass effect tends to increase as the dosage form is placed deeper into the rectum. Solid suppositories represent greater than 98% of all rectal dosage forms.
Rectal Route of Drug Administration Synonyms
Rectal Route of Administration, Per Rectum, RECTAL, Rectal
Terms in Rectal Route of Drug Administration category
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