Reticulon-4

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Reticulon-4

Reticulon-4 Definition

Nogo are high molecular weight transmembrane inhibitors of neurite out-growth found in CNS myelin. Nogo is expressed by oligodendrocytes in white matter of the CNS, but not by Schwann cells in peripheral nerves. The C-terminal region shares homology with neuroendocrine-specific proteins and other members of the reticulon gene family. NOGO consists of a putative large extracellular domain with seven predicted N-linked glycosylation sites, two or three transmembrane domains, and a short C-terminal region. An extracellular domain of NOGO inhibits axonal extension but does not alter non-neuronal cell morphology. Nogo A, B, and C are encoded as splice variants of a single gene. (from OMIM 604475 and NCI)

Reticulon-4 Synonyms

Reticulon 4, Neurite Growth Inhibitor 220, Neurite Outgrowth Inhibitor, Neuroendocrine-Specific Protein C Like (foocen), Nogo-A

Terms in Reticulon-4 category

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