Cancer Terms

Retinoblastoma-Like-2 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Cell Cycle Protein -> Retinoblastoma-Like-2 Protein

Retinoblastoma-Like-2 Protein Definition

Expressed only in G0 by human RBL2 Gene (RB Family), 1139-aa 128-kDa nuclear Retinoblastoma-Like 2 protein binds to adenovirus E1A protein and to cyclins A and E, associates preferentially with E2F5, inhibits E2F-mediated trans-activation, and may function in cell cycle regulation. Ser-672 phosphorylation in G1 leads to ubiquitin-dependent proteolysis of RBL2. (NCI)

Retinoblastoma-Like-2 Protein Synonyms

Retinoblastoma-Like 2, 130 kDa Retinoblastoma-Associated Protein, PRB2, RBL2, RBR2, Retinoblastoma-Like Protein 2, p130

Terms in Retinoblastoma-Like-2 Protein category



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