Riboadenylate Transferase

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Nucleotidyltransferase -> Polymerase -> RNA Polymerase -> Riboadenylate Transferase

Riboadenylate Transferase Definition

Nuclear or cytoplasmic human Riboadenylate Transferases (Poly A Polymerase Family) catalyze template-independent post-transcriptional extension of the 3 prime end of an RNA strand by nonspecific and CPSF/AAUAAA-dependent polyadenylation activity during eukaryotic mRNA maturation. The N-terminal region appears required for nonspecific polymerase activity, while the N- and C-termini are required for specific polymerase activity. Specificity may occur through C-terminus interaction with CPSF, regulated by phosphorylation. The poly(A) reaction involves endoribonucleolytic pre-RNA cleavage at the poly(A) site and synthesis of the poly(A) tail. (NCI)

Riboadenylate Transferase Synonyms

Riboadenylate Transferase, Polynucleotide Adenylyltransferase

Terms in Riboadenylate Transferase category

Polynucleotide Adenylyltransferase Alpha
Polynucleotide Adenylyltransferase Beta
Polynucleotide Adenylyltransferase Gamma